  |
|
|
Department of Psychology Ph: (619) 594-5358 Life Sciences 110
|
Department of Psychology Office Location: Alv 6363/200K Research Interests It is well known that prenatal exposure to alcohol can affect the developing embryo and fetus and importantly can cause alterations in the normal development of brain and behavior. Dr. Riley's research focuses on these changes, how they are produced, and how we might intervene to mitigate them. Using a multidisciplinary approach, including behavioral assessments, neuropsychological testing and brain imaging, and collaborations with scientists from SDSU, UCSD, and the Scripps Research Institute, a myriad of effects has been reported. In terms of changes in brain, alterations in the basal ganglia, corpus callosum, cerebellum, and various areas of the cortex have been reported. Deficits in executive functioning, motor behaviors, and a variety of neuropsychological impairments have been examined. Besides a continuation of these descriptive changes, recent studies consist of functional imaging (fMRI) and correlational studies between brain structural alterations and behavioral changes in an attempt to establish structure-function relationships. A recent collaborative study with the Institute of Psychiatry in Moscow, Russia is investigating behavioral effects in a group of alcohol-exposed orphans residing in Moscow. Pre and Postdoctoral students and fellows have a wide variety of opportunities participating in these studies, and in extending the ongoing investigations depending upon available resources and the expertise each fellow brings to the laboratory. Publications Hughes , S.C. , Chambers, C.D., Kassem, N., Wahlgren, D.R., Larson, S., Riley, E.P., and Hovell, M.F. Inconsistent report of pre-pregnancy-recognition alcohol use by Latinas. Maternal and Child Health Journal, 2009; In press. McGee, C.L., Bjorkquist, O.A., Price, J.M., Mattson, S.N., and Riley, E.P. Social information processing skills in children with histories of heavy prenatal alcohol exposure. Journal of Abnormal Child Psychology, 2009; In press. Coldren, C.D., Lai, Z., Shragg, P., Rossi, E., Zuffardi, O., Mattina, T., Ivy, D.D., Curfs, L., Mattson, S.N., Riley, E.P., Treier, M., and Grossfeld, P.D. Comparative genomic hybridization mapping suggests a role for BSX and Neurogranin in neurocognitive and behavioral defects in the 11q terminal deletion disorder (Jacobsen syndrome). Neurogenetics, 2009;10:89-95. McGee, C.L., Bjorkquist, O.A., Riley, E.P., and Mattson, S.N. Impaired language performance in young children with heavy prenatal alcohol exposure. Neurotoxicology and Teratology, 2009;31:71–75. Simmons, R.W., Levy, S.S., Riley, E.P., Madra, N.M., and Mattson, S.N. Central and peripheral timing variability in children with heavy prenatal alcohol exposure. Alcoholism: Clinical and Experimental Research, 2009;33:400-407. Fryer, S.L., Schweinsburg, B.C., Bjorkquist, O.A., Frank, L.R., Mattson, S.N., Spadoni, A.D., and Riley, E.P. Characterization of white matter microstructure in fetal alcohol spectrum disorders. Alcoholism: Clinical and Experimental Research, 2009;33:1-8. Riley, E.P., Mattson, S.N., and Thomas, J.D. Fetal Alcohol Syndrome. In: L. R. Squire (Ed.), Encyclopedia of Neuroscience, Volume 4. Oxford : Academic Press, 2009;213-220. Guerri, C., Bazinet, A., and Riley, E.P. Foetal alcohol spectrum disorders and alterations in brain and behaviour. Alcohol and Alcoholism, 2009;44:108-114. Mattson, S.N., Fryer, S.L., McGee, C.L., and Riley, E.P. Fetal alcohol syndrome. In C.A. Nelson and M. Luciana (Eds.), Handbook of developmental cognitive neuroscience (2nd ed.). Cambridge , MA : MIT Press, 2008;643-652. McGough, N.N.H., Thomas, J.D., Dominguez, H.D., and Riley, E.P. Insulin-like growth factor-I mitigates motor coordination de?cits associated with neonatal alcohol exposure in rats. Neurotoxicology and Teratology, 2008;31:40-48. Fang, S., McLaughlin, J., Fang, J., Huang, J., Autti-Ramo, I., Fagerlund, Å., Jacobson, S.W., Robinson, L.K., Hoyme, H.E., Mattson, S.N., Riley, E., Zhou, F., Ward, R., Moore, E.S., and Foroud, T. Automated diagnosis of fetal alcohol syndrome using 3D facial image analysis. Orthodontics and Craniofacial Research, 2008;11:162-171. McGee, C.L., Schonfeld, A.M., Roebuck-Spencer, T.M., Riley, E.P., and Mattson, S.N. Children with heavy prenatal alcohol exposure demonstrate deficits on multiple measures of concept formation. Alcoholism: Clinical and Experimental Research, 2008;32(8):1388-1397. McGee, C.L., Fryer, S.L., Bjorkquist, O.A., Mattson, S.N., and Riley, E.P. Deficits in social problem solving in adolescents with prenatal exposure to alcohol. American Journal on Drug and Alcohol Abuse, 2008;34(4):423-431. Vaurio, L., Riley, E.P., and Mattson, S.N. Differences in executive functioning in children with heavy prenatal alcohol exposure or attention-deficit/hyperactivity disorder. Journal of the International Neuropsychological Society, 2008;14(1):119-129. Sowell, E.R., Mattson, S.N., Kan, E., Thompson, P.M., Riley, E.P., and Toga, A.W. Abnormal cortical thickness and brain-behavior correlation patterns in individuals with heavy prenatal alcohol exposure. Cerebral Cortex, 2008;18(1):136-144. Arenson, A., Bakhireva, L., Chambers, T., Deximo, C., Foroud, T., Jacobson, J., Jacobson, S., Jones, K.L., Mattson, S., May, P., Moore, E., Ogle, K., Riley, E., Robinson, L., Rogers, J., Streissguth, A., Tavares, M., Urbanski, J., Yezerets, H., and Stewart, C.A. Implementation of a distributed architecture for managing collection and dissemination of data for fetal alcohol spectrum disorders research. In W. Dubitzky, A. Schuster, P.M.A. Sloot, M. Schroeder, and M. Romberg (Eds.), Distributed, High-Performance and Grid Computing in Computational Biology, Vol. 4360. Heidelberg : Springer Berlin , 2007. Riley, E.P. and Mattson, S.N. Effects of prenatal alcohol exposure on brain and behavior. Neurotoxicology and Teratology, 2007;29:400. McGee, C.L., and Riley, E.P. Social and behavioral functioning in individuals with prenatal alcohol exposure. International Journal on Disability and Human Development. 2007;6(4):369-382. Fryer, S.L., Tapert, S.F., Mattson, S.N., Paulus, M.P., Spadoni, A.D., and Riley, E.P. Prenatal alcohol exposure affects frontal-striatal BOLD response during inhibitory control. Alcoholism: Clinical and Experimental Research, 2007;31:1415-1424. Fryer, S.L., McGee, C.L., Matt, G.E., Riley, E.P., and Mattson, S.N. Evaluation of psychopathological conditions in children with heavy prenatal alcohol exposure. Pediatrics, 2007;119:e733-e741. Spadoni, A.D., McGee, C.L., Fryer, S.L., and Riley, E.P. Neuroimaging and fetal alcohol spectrum disorders. Neuroscience Biobehavioral Reviews, 2007;31:239-245. PMCID: PMC1820628 Fagerlund, A., Heikkinen, S., Autti-Ramo, I. , Korkman, M., Timonen, M., Kuusi, T., Riley, E.P., and Lundbom, N. Brain metabolic alterations in adolescents and young adults with fetal alcohol spectrum disorders. Alcoholism: Clinical and Experimental Research, 2006;30:2097-2104. Bell , M.C. and Riley, E.P. Memory and perseveration on a win-stay, lose-shift task in rats exposed neonatally to alcohol. Journal of Studies on Alcohol, 2006;67:851-860. Jones, K.L., Robinson, L.K., Bakhireva, L.N., Marintcheva, G., Storojev, V., Strahova, A., Sergeevskaya, S., Budantseva, S. Mattson, S.N., Riley, E.P., and Chambers, C.D. Accuracy of the diagnosis of physical features of fetal alcohol syndrome by pediatricians after specialized training. Journal of Pediatrics, 2006;118:e1734-e1738. Jones, K.L., Chambers, C., Hill, L., Hull , A., and Riley, E.P. Alcohol use in pregnancy: Inadequate recommendations for an increasing problem. British Journal of Obstetrics and Gynecology, 2006;113:967-968. McGee, C.L. and Riley, E.P. Brain Imaging and FASD. ANNALI of Instituto Superiore di Sanita, 2006;42:46-52. Sakata-Haga, H., Dominguez, H.D., Sei, H., Fukui , Y., Riley, E.P., and Thomas, J.D. Alterations in circadian rhythm phase shifting ability in rats following ethanol exposure during the third trimester brain growth spurt. Alcoholism: Clinical and Experimental Research, 2006;30:899-907. Simmons, R.W., Thomas, J.D., Levy, S.S., and Riley, E. P. Motor response selection in children with fetal alcohol spectrum disorders. Neurotoxicology Teratology, 2006;28:278-285. O'Hare, E.D., Kan, E., Yoshii, J., Mattson, S.N., Riley, E.P., Thompson, P.M., Toga A.W., and Sowell E.R. Mapping cerebellar vermal morphology and cognitive correlates in prenatal alcohol exposure. Neuroreport, 2005;16:1285-1290. Chambers, C.D., Hughes, S, Meltzer, S.B., Wahlgren, D., Kassem, N., Larson, S., Riley, E.P., and Hovel, M.F. Alcohol consumption among low-income pregnant latinas. Alcoholism: Clinical and Experimental Research, 2005;29:2022-2028. Schonfeld, A.M., Mattson, S.N., and Riley, E.P. Moral maturity and delinquency after prenatal alcohol exposure. Journal of Studies on Alcohol, 2005;66:545-554. Strömland, K., Mattson , S.N., Adnams, C.M., Autti-Rämö, I., Riley, E.P., and Warren , K.R. Fetal alcohol spectrum disorders: An international perspective. Alcoholism: Clinical and Experimental Research, 2005;29:1121-1126. Fryer, S.L., McGee, C.L., Spadoni, A.D., and Riley, E.P. Influence of alcohol on the structure of the developing human brain. In M.M. Miller (Ed.), Development of the Mammalian Central Nervous System: Lessons Learned from Studies on Alcohol and Nicotine Exposure. Oxford University Press, 2005. Riley, E.P., Fryer, S.L., and McGee, C.L. Behavioral teratogenicity of alcohol: Thirty years of hindsight. In D. E. Cohen (Ed.), Proceedings of the 30th Anniversary Conference: The Truth and Consequences of Fetal Alcohol Syndrome. New Jersey Department of Human Services, 2005. Huang, J., Jain, A., Fang, S., and Riley, E.P. Using facial images to diagnose fetal alcohol syndrome (FAS). International Conference on Information Technology: Coding and Computing, 2005;2:66-71. Riley, E.P. and McGee, C.L. Fetal alcohol spectrum disorders: An overview with emphasis on changes in brain and behavior. Experimental Biology and Medicine, 2005;230:357-365. Slawecki, C.J., Thomas, J.D., Riley, E.P., and Ehlers, C.L. Neurophysiologic consequences of neonatal ethanol exposure in the rat. Alcohol, 2004;34:187-196. Roebuck-Spencer, T.M., Mattson, S.N., Marion , S.D. , Brown, W.S., and Riley, E.P. Bimanual coordination in alcohol-exposed children: Role of the corpus callosum. Journal of the International Neuropsychological Society, 2004;10:536-548. Bigliocchi, M., Lo Mele, L., Stasolla, A., Kharrub, Z., Riley, E.P., Ceccanti, M., Attilia, M.L., Giacomelli, S., Masciangelo, R., and Marini, M. MRI and muscle signal intensities in alcoholics compared with control subjects. Alcoholism: Clinical and Experimental Research, 2004;28:1875-1880. Thomas, J.D., Garcia, G.G., Dominguez, H.D., and Riley, E.P. Administration of eliprodil during ethanol withdrawal in the neonatal rat attenuates ethanol-induced learning deficits. Psychopharmacology, 2004;175:189-195. Lee, K.T., Mattson, S.N., and Riley, E.P. Classifying children with heavy prenatal alcohol exposure using measures of attention. Journal of the International Neuropsychological Society, 2004;10:271-277. Riley, E.P., McGee, C.L., and Sowell, E.R. Teratogenic effects of alcohol: A decade of brain imaging. American Journal of Medical Genetics Part C. Seminars in Medical Genetics, 2004;127C:35-41. Mattson, S.N., Jones, K.L., Gramling, L., Goodman, A.M., Riley, E. P., Harris, J. A., and Chambers, C.D. Neurodevelopmental follow-up of children of women infected with varicella during pregnancy: A prospective study. The Pediatric Infectious Disease Journal, 2003;2:819-823. Riley, E.P. FAE/FAS: Prevention, Intervention and Support Services. Commentary on Burd and Juelson, Coles, and O'Malley and Streissguth. In: R.E. Tremblay, R.G. Barr, and R.D.V. Peters (Eds.), Encyclopedia on Early Childhood Development, 2003;1-7. Riley, E.P. Commentary on E. L. Abel's “Paternal Contribution of FAS." Addiction Biology, 2004;9:135-136. Thomas, J.D., Leany, B.D., Riley, E.P. Differential vulnerability to motor deficits in second replicate HAS and LAS rats following neonatal alcohol exposure. Pharmacology, Biochemistry, and Behavior, 2003;75(1):17-24. Riley, E.P., Mattson, S.N., and Thomas, J.D. Fetal Alcohol Syndrome. In: G. Adelman & B.H. Smith (Eds), Encyclopedia of Neuroscience, Third Edition. [on CD ROM], Oxford: Elsevier Science Publishers, 2003. Riley, E.P., Mattson, S.N., Li, T.K., Jacobson, S.W., Coles, C.D., Kodituwakku, P.W., Adnams, C.M., Korkman, M.I. Neurobehavioral consequences of prenatal alcohol exposure: An international perspective. Alcoholism: Clinical and Experimental Research, 2003;27(2): 362-373. Riley, E.P., Guerri, C., Calhoun, F., Charness, M.E., Foroud, T., Li, T.K., Mattson, S., May, P., Warren, K. Prenatal alcohol exposure: advancing knowledge through international collaborations. Alcoholism: Clinical and Experimental Research, 2003;27:118-135. Weber, M.K., Floyd, R. L., Riley, E.P., and Snider, D.E. National task force on fetal alcohol syndrome and fetal alcohol effect: Defining the national agenda for fetal alcohol syndrome and other prenatal alcohol-related effects. Morbidity and Mortality Weekly Report, 2002;51:9-12. Wass, T.S., Simmons, R.W., Thomas, J.D., and Riley, E.P. Timing accuracy and variability in children with prenatal exposure to alcohol. Alcoholism: Clinical and Experimental Research, 2002;26:1887-96. Thomas, J.D., Fleming, S.L., and Riley, E.P. Administration of low doses of MK-801 during ethanol withdrawal in the developing rat pup attenuates alcohols teratogenic effects. Alcoholism: Clinical and Experimental Research, 2002;26:1307-1313. Sowell, E.R., Thompson, P.M., Peterson, B.S., Mattson, S.N., Welcome, S.E., Henkenius, A.L., Riley, E.P., Jernigan, T.L., and Toga, A.W. Mapping cortical gray matter asymmetry patterns in adolescents with heavy prenatal alcohol exposure. NeuroImage, 2002;17:1807-19. Sowell, E.R., Thompson, P.M., Mattson, S.N., Tessner, K.D., Jernigan, T.L., Riley, E.P., and Toga, A.W. Regional brain shape abnormalities persist into adolescence after heavy prenatal alcohol exposure. Cerebral Cortex, 2002;12:856-865. Simmons, R.W., Wass, T., Thomas, J.D., and Riley, E.P. Fractionated simple and choice reaction time in children with prenatal exposure to alcohol. Alcoholism: Clinical and Experimental Research, 2002;26:1412-9. Roebuck, T.M. Mattson, S.N. and Riley, E.P. Interhemispheric transfer in children with heavy prenatal alcohol exposure. Alcoholism: Clinical and Experimental Research, 2002;26:1863-71. Thomas, J.D., Fleming, S.L., & Riley, E.P. MK-801 can exacerbate or attenuate behavioral alterations associated with neonatal alcohol exposure in the rat, depending on the timing of administration. Alcoholism: Clinical and Experimental Research, 2001;25:764-773. Sowell, E.R., Thompson, P.M., Mattson, S.N., Tessner, K.D., Jernigan, T.L., Riley, E.P., and Toga, A.W. Voxel-based morphometric analyses of the brain in children and adolescents prenatally exposed to alcohol. Neuroreport, 2001;12:515-523. Sowell, E.R., Mattson, S.N., Thompson, P.M., Jernigan, T.L., Riley, E.P., and Toga, A.W. Mapping callosal morphology and cognitive correlates: Effects of heavy prenatal alcohol exposure. Neurology, 2001;57:235-244. Schonfeld, A.M., Mattson, S.N., Lang, A.R., Delis, D.C., and Riley, E.P. Verbal and nonverbal fluency in children with heavy prenatal alcohol exposure. Journal of Studies on Alcohol, 2001;62:239-246. Riley, E.P., Thomas, J.D., Goodlett, C.R., Klintsova, A.Y., Greenough, W.T., Hungund, B.L., Zhou, F., Sari, Y., Powrozek, T., Li, T.-K. Fetal Alcohol Effects: Mechanisms and Treatment. Alcoholism: Clinical and Experimental Research, 2001;25:110S-116S. Mattson, S.N., Schonfeld, A.M., and Riley, E. P. Teratogenic Effects of Alcohol on Brain and Behavior. Alcohol Research and Health, 25(3), 185-191, 2001 Sowell ER. Mattson SN. Thompson PM. Jernigan TL. Riley EP. Toga AW. Mapping callosal morphology and cognitive correlates: effects of heavy prenatal alcohol exposure. Neurology. 57(2):235-44, 2001 Riley EP. Thomas JD. Goodlett CR. Klintsova AY. Greenough WT. Hungund BL. Zhou F. Sari Y. Powrozek T. Li TK. Fetal alcohol effects: mechanisms and treatment. Alcoholism: Clinical & Experimental Research. 25(5 Suppl ISBRA):110S-116S, 2001 Schonfeld AM. Mattson SN. Lang AR. Delis DC. Riley EP. Verbal and nonverbal fluency in children with heavy prenatal alcohol exposure. Journal of Studies on Alcohol. 62(2):239-46, 2001 Archibald SL. Fennema-Notestine C. Gamst A. Riley EP. Mattson SN. Jernigan TL. Brain dysmorphology in individuals with severe prenatal alcohol exposure. Developmental Medicine & Child Neurology. 43(3):148-54, 2001 Sowell ER. Thompson PM. Mattson SN. Tessner KD. Jernigan TL. Riley EP. Toga AW. Voxel-based morphometric analyses of the brain in children and adolescents prenatally exposed to alcohol. NeuroReport. 12(3):515-23, 2001 Mattson SN. Riley EP. Parent ratings of behavior in children with heavy prenatal alcohol exposure and IQ-matched controls. Alcoholism: Clinical & Experimental Research. 24(2):226-31, 2000 Mattson SN. Goodman AM. Caine C. Delis DC. Riley EP. Executive functioning in children with heavy prenatal alcohol exposure. Alcoholism: Clinical & Experimental Research. 23(11):1808-15, 1999 Mattson SN. Riley EP. Implicit and explicit memory functioning in children with heavy prenatal alcohol exposure. Journal of the International Neuropsychological Society. 5(5):462-71, 1999 Roebuck TM. Mattson SN. Riley EP. Behavioral and psychosocial profiles of alcohol-exposed children. Alcoholism: Clinical & Experimental Research. 23(6):1070-6, 1999 Roebuck TM. Simmons RW. Richardson C. Mattson SN. Riley EP. Neuromuscular responses to disturbance of balance in children with prenatal exposure to alcohol. Alcoholism: Clinical & Experimental Research. 22(9):1992-7, 1998 Thomas SE. Kelly SJ. Mattson SN. Riley EP. Comparison of social abilities of children with fetal alcohol syndrome to those of children with similar IQ scores and normal controls. Alcoholism: Clinical & Experimental Research. 22(2):528-33, 1998 Roebuck TM. Mattson SN. Riley EP. A review of the neuroanatomical findings in children with fetal alcohol syndrome or prenatal exposure to alcohol. Alcoholism: Clinical & Experimental Research. 22(2):339-44, 1998 Mattson SN. Riley EP. A review of the neurobehavioral deficits in children with fetal alcohol syndrome or prenatal exposure to alcohol. Alcoholism: Clinical & Experimental Research. 22(2):279-94, 1998 |
|
© 2004 SDSU Department of Psychology - All Rights Reserved |
|
||||||||
