picture of dr. Mueller



Ralph-Axel Müller, Ph.D





Dept. of Psychology, San Diego State University

Dept. of Cognitive Science, University of California San Diego

Lab: Brain Development Imaging
Office and Lab: San Diego State University, MC 1863
6363 Alvarado Ct., #225 E San Diego, CA 92120

Tel. Office: (619)-594-5276 Lab: (619)-594-0176 Fax: (619)-594-8707

Email: rmueller@mail.sdsu.edu

Research Interests

Brain Development Imaging Lab – We study functional and anatomical brain development in neurotypical children and those with developmental disorders (especially autism). Research applies multimodal magnetic resonance imaging techniques (functional and functional connectivity MRI, anatomical volumetrics, diffusion tensor imaging and tractography, MR spectroscopy), as well as eye-tracking, behavioral, and neuropsychological measures.

Research Keywords: Brain development, autism spectrum disorders, functional MRI, diffusion tensor imaging, brain networks, cognition, emotion, sensorimotor function

Recent Publications

Shukla, D.K., Keehn, B. & Müller, R.-A. (2011) Tract-specific analyses of diffusion tensor imaging show widespread white matter compromise in autism spectrum disorder. Journal of Child Psychology and Psychiatry and Allied Disciplines, 52(3), 286-95. http://www.ncbi.nlm.nih.gov/pubmed/21073464

Müller, R.-A., Shih, P., Keehn, B., Deyoe, J.R., Leyden, K.M. & Shukla, D.K. (2011) Underconnected, but how? A survey of functional connectivity MRI studies in autism spectrum disorders. Cerebral Cortex, 21(10), 2233-43. http://www.ncbi.nlm.nih.gov/pubmed/21378114

Shih, P., Keehn, B., Oram, J.K., Leyden, K.M., Keown, C.L. & Müller, R.-A. (2011) Functional differentiation of posterior superior temporal sulcus in autism: a functional connectivity magnetic resonance imaging study. Biological Psychiatry, 70(3), 270-7. http://www.ncbi.nlm.nih.gov/pubmed/21601832

Shen, M.D., Shih, P., Öttl, B., Keehn, B.M., Leyden, K.M., Gaffrey, M.S. & Müller, R.-A. (2012) Atypical lexicosemantic function of extrastriate cortex in autism spectrum disorder: Evidence from functional and effective connectivity. Neuroimage, 62, 1780-91. http://www.ncbi.nlm.nih.gov/pubmed/22699044

Keehn, B., Shih, P., Brenner, L., Townsend, J. & Müller, R.-A. (2013) Functional connectivity for an “island of sparing” in autism spectrum disorder: An fMRI study of visual search. Human Brain Mapping 34, 2524-37. http://www.ncbi.nlm.nih.gov/pubmed/22495745

Nair, A., Treiber, J.M., Shukla, D.K., Shih, P. & Müller, R.-A. (2013) Thalamocortical connectivity in autism spectrum disorder: A study of functional and anatomical connectivity. Brain, 136(Pt 6), 1942-55. http://www.ncbi.nlm.nih.gov/pubmed/23739917.

Keown, C.L., Shih, P., Nair, A., Peterson, N. & Müller, R.-A. (2013) Local functional overconnectivity in posterior brain regions is associated with symptom severity in autism spectrum disorders. Cell Reports. E-pub. http://www.ncbi.nlm.nih.gov/pubmed/24210815.

Cardinale, R.C., Shih, P., Fishman, I., Ford, L.M. & Müller, R.-A. (2013) Pervasive rightward asymmetry shifts of functional networks in autism spectrum disorder: An fMRI study using independent component analysis. JAMA Psychiatry 70, 975-82. http://www.ncbi.nlm.nih.gov/pubmed/23903586.

Nair, A., Keown, C.L., Datko, M.C., Shih, P., Keehn, B.M. & Müller, R.-A. (in press) Impact of methodological variables on functional connectivity findings in Autism Spectrum Disorders. Human Brain Mapping. http://www.ncbi.nlm.nih.gov/pubmed/24452854.

Fishman, I., Keown, C.L., Lincoln, A.J., Pineda, J.A. & Müller, R.-A. (2014) Atypical ‘cross-talk’ between mentalizing and mirror neuron networks in autism spectrum disorder. JAMA Psychiatry 71, 751-60. http://www.ncbi.nlm.nih.gov/pubmed/24740586