close up of axel Ralph-Axel Müller, Ph.D


Dept. of Psychology, San Diego State University

Dept. of Cognitive Science, University of California San Diego

Lab: Brain Development Imaging
Office and Lab: San Diego State University, MC 1863
6363 Alvarado Ct., #225 E San Diego, CA 92120

Tel. Office: (619)-594-5276 Lab: (619)-594-0176 Fax: (619)-594-8707 


Research Interests

Brain Development Imaging Lab – Multimodal brain imaging (functional and anatomical MRI, functional connectivity MRI, diffusion weighted imaging etc.) to investigate brain biomarkers in children and adults with autism spectrum disorders; dynamic aspects of brain function and connectivity; brain organization for language in typically developing children; data-driven image analysis

Research Keywords: Brain development, autism spectrum disorders, functional MRI, diffusion tensor imaging, brain networks, cognition, emotion, sensorimotor function

Recent Publications

Shukla, D.K., Keehn, B. & Müller, R.-A. (2011) Tract-specific analyses of diffusion tensor imaging show widespread white matter compromise in autism spectrum disorder. Journal of Child Psychology and Psychiatry and Allied Disciplines, 52(3), 286-95.

Müller, R.-A., Shih, P., Keehn, B., Deyoe, J.R., Leyden, K.M. & Shukla, D.K. (2011) Underconnected, but how? A survey of functional connectivity MRI studies in autism spectrum disorders. Cerebral Cortex, 21(10), 2233-43.

Shih, P., Keehn, B., Oram, J.K., Leyden, K.M., Keown, C.L. & Müller, R.-A. (2011) Functional differentiation of posterior superior temporal sulcus in autism: a functional connectivity magnetic resonance imaging study. Biological Psychiatry, 70(3), 270-7.

Shen, M.D., Shih, P., Öttl, B., Keehn, B.M., Leyden, K.M., Gaffrey, M.S. & Müller, R.-A. (2012) Atypical lexicosemantic function of extrastriate cortex in autism spectrum disorder: Evidence from functional and effective connectivity. Neuroimage, 62, 1780-91.

Keehn, B., Shih, P., Brenner, L., Townsend, J. & Müller, R.-A. (2013) Functional connectivity for an “island of sparing” in autism spectrum disorder: An fMRI study of visual search. Human Brain Mapping 34, 2524-37.

Nair, A., Treiber, J.M., Shukla, D.K., Shih, P. & Müller, R.-A. (2013) Thalamocortical connectivity in autism spectrum disorder: A study of functional and anatomical connectivity. Brain, 136(Pt 6), 1942-55.

Keown, C.L., Shih, P., Nair, A., Peterson, N. & Müller, R.-A. (2013) Local functional overconnectivity in posterior brain regions is associated with symptom severity in autism spectrum disorders. Cell Reports. E-pub.

Cardinale, R.C., Shih, P., Fishman, I., Ford, L.M. & Müller, R.-A. (2013) Pervasive rightward asymmetry shifts of functional networks in autism spectrum disorder: An fMRI study using independent component analysis. JAMA Psychiatry 70, 975-82.

Nair, A., Keown, C.L., Datko, M.C., Shih, P., Keehn, B.M. & Müller, R.-A. (in press) Impact of methodological variables on functional connectivity findings in Autism Spectrum Disorders. Human Brain Mapping.

Fishman, I., Keown, C.L., Lincoln, A.J., Pineda, J.A. & Müller, R.-A. (2014) Atypical ‘cross-talk’ between mentalizing and mirror neuron networks in autism spectrum disorder. JAMA Psychiatry 71, 751-60.