picture of dr. Mueller



Ralph-Axel Müller, Ph.D





Dept. of Psychology, San Diego State University

Dept. of Cognitive Science, University of California San Diego

Lab: Brain Development Imaging
Office and Lab: San Diego State University, MC 1863
6363 Alvarado Ct., #225 E San Diego, CA 92120

Tel. Office: (619)-594-5276 Lab: (619)-594-0176 Fax: (619)-594-8707

Email: rmueller@mail.sdsu.edu

Research Interests

Brain Development Imaging Lab - We study functional and anatomical brain development in neurotypical children and those with developmental disorders (especially autism). Research applies multimodal magnetic resonance imaging techniques (functional and functional connectivity MRI, anatomical volumetrics, diffusion tensor imaging and tractography, MR spectroscopy), as well as eye-tracking, behavioral, and neuropsychological measures.

Research Keywords: Brain development, autism spectrum disorders, functional MRI, diffusion tensor imaging, brain networks, cognition, emotion, sensorimotor function

Recent Publications

Shukla, D.K., Keehn, B. & Müller, R.-A. (2011) Tract-specific analyses of diffusion tensor imaging show widespread white matter compromise in autism spectrum disorder. Journal of Child Psychology and Psychiatry and Allied Disciplines, 52(3), 286-95. http://www.ncbi.nlm.nih.gov/pubmed/21073464

Müller, R.-A., Shih, P., Keehn, B., Deyoe, J.R., Leyden, K.M. & Shukla, D.K. (2011) Underconnected, but how? A survey of functional connectivity MRI studies in autism spectrum disorders. Cerebral Cortex, 21(10), 2233-43. http://www.ncbi.nlm.nih.gov/pubmed/21378114

Shukla, D.K., Keehn, B., Smylie, D.M. & Müller, R.-A. (2011) Microstructural abnormalities of short-distance whitematter tracts in autism spectrum disorder. Neuropsychologia, 49(5), 1378-82.  http://www.ncbi.nlm.nih.gov/pubmed/21333661

Shih, P., Keehn, B., Oram, J.K., Leyden, K.M., Keown, C.L. & Müller, R.-A. (2011) Functional differentiation of posterior superior temporal sulcus in autism: a functional connectivity magnetic resonance imaging study. Biological Psychiatry, 70(3), 270-7. http://www.ncbi.nlm.nih.gov/pubmed/21601832 

Keehn, B., Shih, P., Brenner, L., Townsend, J. & Müller, R.-A. (2012) Functional connectivity for an “island of sparing” in autism spectrum disorder: An fMRI study of visual search. HumanBrain Mapping, E-pub.  http://www.ncbi.nlm.nih.gov/pubmed/22495745

Shen, M.D., Shih, P., Öttl, B., Keehn, B.M., Leyden, K.M., Gaffrey, M.S. & Müller, R.-A. (2012) Atypical lexicosemantic function of extrastriate cortex in autism spectrum disorder:Evidence from functional and effective connectivity. Neuroimage, 62, 1780-91. http://www.ncbi.nlm.nih.gov/pubmed/22699044