picture of dr. brasser

Susan M. Brasser, Ph.D.
Associate Professor
Associate Advisor, Master’s Program

Department of Psychology
San Diego State University
6330 Alvarado Ct., Ste.231
San Diego, CA 92120-4913

Office Location: ALV-6330/231

Mail Code: 1863
Phone: (619) 594-8652
FAX: (619) 594-1895
Email: sbrasser@mail.sdsu.edu

Research Interests

My primary interests are in studying the physiological mechanisms of action of ethanol on the nervous system that regulate behavioral ingestion of the drug. Goals are to identify specific substrates with which ethanol interacts that are involved in controlling intake and to determine how variation in those substrates leads to excessive consumption. My research utilizes pharmacological and genetic manipulations (i.e., selectively bred lines and knockout models) combined with quantitative measures of ingestive behavior and in vivo electrophysiology to address these issues.

One current area of investigation focuses on the interaction of ethanol with gustatory receptors and central neural circuits involved in processing appetitive taste information and the contribution of ethanol-induced activation of these circuits to alcohol consumption. A second related area of interest centers on the trigeminal processing of alcohol and the role of ethanol stimulation of oral trigeminal pathways in modulating alcohol preference.

Research Keywords: Addiction, Alcohol, Ethanol, Chemosensory, Taste, Trigeminal

Lab: Alcohol Sensory Processing/Behavioral Neurobiology

Education

Ph.D. Institution: State University of New York at Binghamton
Postdoctoral: Johns Hopkins University School of Medicine

Recent Publications

Godfrey J, Jeanguenin L, Castro N, Olney JJ, Dudley J, Pipkin J, Walls SM, Wang W, Herr DR, Harris GL, Brasser SM. Chronic voluntary ethanol consumption induces favorable ceramide profiles in selectively bred alcohol-preferring (P) rats. PLoS One. 2015 Sep 25;10(9):e0139012. PMID: 26405804

Klarich DS, Brasser SM, Hong MY. Moderate alcohol consumption and colorectal cancer risk. Alcohol Clin Exp Res. 2015 Aug;39(8):1280-91. Epub 2015 Jun 25. PMID: 26110674

Brasser SM, Castro N, Feretic B. Alcohol sensory processing and its relevance for ingestion. Physiol Behav. 2015 Sep 1;148:65-70. Epub 2014 Oct 7. PMID: 25304192

Brasser SM, Silbaugh BC, Ketchum MJ, Olney JJ, Lemon CH. Chemosensory responsiveness to ethanol and its individual sensory components in alcohol-preferring, alcohol-nonpreferring and genetically heterogeneous rats. Addict Biol. 2012 Mar;17(2):423-36. Epub 2011 Nov 29. PMID: 22129513

Lemon CH, Wilson DM, Brasser SM. Differential neural representation of oral ethanol by central taste-sensitive neurons in ethanol-preferring and genetically heterogeneous rats. J Neurophysiol. 2011 Dec;106(6):3145-56. Epub 2011 Sep 14.PMID: 21918002

Brasser SM, Norman MB, Lemon CH. T1r3 taste receptor involvement in gustatory neural responses to ethanol and oral ethanol preference. Physiol Genomics. 2010; 41:232-243. Epub 2010 Feb 9. PMID: 20145204

Ellingson JM, Silbaugh BC, Brasser SM.  Reduced oral ethanol avoidance in mice lacking transient receptor potential channel vanilloid receptor 1. Behav Genet. 2009 Jan;39(1):62-72. Epub 2008 Oct 7. PMID: 18839303

Brasser SM, Mozhui K, Smith DV. Differential covariation in taste responsiveness to bitter stimuli in rats. Chem Senses. 2005 Nov;30(9):793-9. Epub 2005 Nov 2. PMID: 16267162

Donny EC, Brasser SM, Bigelow GE, Stitzer ML, Walsh SL. Methadone doses of 100 mg or greater are more effective than lower doses at suppressing heroin self-administration in opioid-dependent volunteers. Addiction. 2005 Oct;100(10):1496-509. PMID: 16185211

Brasser SM, McCaul ME, Houtsmuller EJ. Alcohol effects during acamprosate treatment: a dose-response study in humans. Alcohol Clin Exp Res. 2004 Jul;28(7):1074-83. PMID: 15252294

Lemon CH, Brasser SM, Smith DV. Alcohol activates a sucrose-responsive gustatory neural pathway. J Neurophysiol. 2004 Jul;92(1):536-44. Epub 2004 Feb 25. PMID: 14985409